Netter's essential biochemistry /
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| Typ dokumentu: | Kniha |
| Jazyk: | Angličtina |
| Vydáno: |
Philadelphia, PA:
Elsevier,
[2018]
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| Témata: | |
| On-line přístup: | Elektronická verze přístupná pouze pro studenty a pracovníky MU |
| Příbuzné jednotky: | Tištěná verze::
Netter's essential biochemistry. |
Obsah:
- Front Cover; Inside Front Cover; Marketing page; Netter's Essential Biochemistry; Copyright Page; Dedication; About the Author; Acknowledgments; Coauthors and Chapter Reviewers; About the Artist; Frank H. Netter, MD; Preface; Table Of Contents; 1 Human Karyotype and the Structure of DNA; Learning Objectives; Synopsis; 1. Chemical Structure of DNA; 2. Hydrogen Bonding Between Complementary Bases; 3. DNA Double Helix; 4. Packing of DNA Double Helices Into Chromatids; 5. Changes in DNA Topology; 6. Human Karyotype; Summary; Further Reading; Review Questions; 2 DNA Repair and Therapy of Cancer.
- Learning ObjectivesSynopsis; 1. Base-Excision Repair; 2. Mismatch Repair; 3. Nucleotide-Excision Repair; 4. Repair of Double-Strand Breaks and Interstrand Crosslinks; 4.1. Nonhomologous End Joining; 4.2. Homologous Recombination Repair (Homology-Directed Repair); 5. DNA Damage Response Halts the Cell Cycle and Regulates Apoptosis; Summary; Further Reading; Review Questions; 3 DNA Replication; Learning Objectives; Synopsis; 1. DNA Replication; 2. Translesion Dna Synthesis; 3. Replication of the Ends of Chromosomes (Telomeres); Summary; Further Reading; Review Questions.
- 4 Clinical Tests Based on DNA or RNALearning Objectives; Synopsis; 1. Conventional Cytogenetics and Fluorescence in Situ Hybridization; 2. DNA Amplification by Polymerase Chain Reaction; 3. Electrophoresis and Melting Curve Analysis of DNA; 4. DNA Microarray-Based Technologies; 5. DNA Sequencing; 5.1. Sanger Sequencing; 5.2. Massive Parallel Sequencing; 6. Selected Clinical Applications of DNA-Based Testing; 6.1. Prenatal Diagnosis; 6.2. Other Common Nucleic Acid-Based Tests; Summary; Further Reading; Review Questions; 5 Basic Genetics for Biochemistry; Learning Objectives; Synopsis.
- 1. Chromosomes and Alleles2. Imprinting and Patterns of Inheritance; 3. Mutations and Markers; Summary; Review Question; 6 Transcription and RNA Processing; Learning Objectives; Synopsis; 1. DNA Methylation and Packing Impede Transcription; 2. The Process of Transcription; 3. Processing of RNA During and After Transcription; 3.1. Capping of Pre-mRNA; 3.2. Polyadenylation of Pre-mRNA; 3.3. Splicing of Pre-mRNA; 3.4. Alternative Splicing of Pre-mRNA; 3.5. Export of mRNA Into the Cytosol; 3.6. Degradation of mRNA; Summary; Further Reading; Review Questions.
- 7 Translation and Posttranslational Protein ProcessingLearning Objectives; Synopsis; 1. Codons and the Genetic Code; 2. Transfer RNAs; 3. Ribosomes Translate mRNA Into Protein; 4. Posttranslational Modification; 4.1. General Comments; 4.2. Glycosylation; 4.3. Acylation With Fatty Acids and Prenylation; 4.4. Phosphorylation, Sulfation, and Nitrosylation; 4.5. Ubiquitylation and SUMOylation; 5. Protein Sorting and Quality Control; Summary; Further Reading; Review Questions; 8 Cell Cycle and Cancer; Learning Objectives; Synopsis; 1. Cell Cycle and Its Regulation.