Variabilita genů renin-angiotenzinového systému u roztroušené sklerózy mozkomíšní
práce se zabývá polymorfismy genů renin-angiotenzinového systému u roztroušené sklerózy. Nejdříve jsme hledali asociaci mezi I/D polymorfismem angiotenzin-konvertujícího enzymu, (-6)A/G a M235T polymorfismem angiotenzinogenu a vnímavostí k roztroušené skleróze. V druhé části výzkumu (genotyp-fenotyp...
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| Format: | Thesis Manuscript |
| Language: | Czech |
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2012
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| Online Access: | http://is.muni.cz/th/21360/lf_d/ |
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| 072 | 7 | |a 616 |x Patologie. Klinická medicína |2 Konspekt |9 14 | |
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| 100 | 1 | |a Hladíková, Magdaléna |7 xx0143543 |% UČO 21360 |4 dis | |
| 242 | 1 | 4 | |a The gene variability of the renin-angiotensin system in multiple sclerosis |y eng |
| 245 | 1 | 0 | |a Variabilita genů renin-angiotenzinového systému u roztroušené sklerózy mozkomíšní |h [rukopis] / |c Magdaléna Hladíková |
| 260 | |c 2012 | ||
| 300 | |a 98, [10] l. | ||
| 500 | |a Vedoucí práce: Pavel Štourač | ||
| 502 | |a Dizertace (Ph.D.)--Masarykova univerzita, Lékařská fakulta, 2012 | ||
| 520 | 2 | |a práce se zabývá polymorfismy genů renin-angiotenzinového systému u roztroušené sklerózy. Nejdříve jsme hledali asociaci mezi I/D polymorfismem angiotenzin-konvertujícího enzymu, (-6)A/G a M235T polymorfismem angiotenzinogenu a vnímavostí k roztroušené skleróze. V druhé části výzkumu (genotyp-fenotypové studii) jsme s využitím Multiple Sclerosis Severity Score podle Roxburgha zjišťovali, zda mají tyto tři polymorfismy vliv na rychlost progrese onemocnění. |% cze | |
| 520 | 2 | 9 | |a Our work deals with gene polymorphisms of the renin-angiotensin system in multiple sclerosis (MS). First, we looked for an association between angiotensin-converting enzyme I/D polymorphism and angiotensinogen (-6)A/G and M235T polymorphisms and MS susceptibility. In the second part of our reasearch (genotype-phenotype study) we investigated whether these three polymorphisms affect the rate of disease progression evaluated by Global Multiple Sclerosis Severity Score according to Roxburgh. |9 eng |
| 650 | 0 | 7 | |a angiotensin konvertující enzym |2 czmesh |
| 650 | 0 | 7 | |a angiotensinogen |2 czmesh |
| 650 | 0 | 7 | |a angiotenzin konvertující enzym |7 ph250750 |2 czenas |
| 650 | 0 | 7 | |a chronicko-progresivní roztroušená skleróza |x genetika |2 czmesh |
| 650 | 0 | 7 | |a polymorfismus genetický |2 czmesh |
| 650 | 0 | 7 | |a renin-angiotensin systém |2 czmesh |
| 650 | 0 | 9 | |a angiotensin converting enzyme |2 eczenas |
| 650 | 0 | 2 | |a Angiotensinogen |
| 650 | 0 | 2 | |a Multiple Sclerosis, Chronic Progressive |
| 650 | 0 | 2 | |a Peptidyl-Dipeptidase A |
| 650 | 0 | 2 | |a Polymorphism, Genetic |
| 650 | 0 | 2 | |a Renin-Angiotensin System |
| 655 | 7 | |a disertace |7 fd132024 |2 czenas | |
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| 700 | 1 | |a Štourač, Pavel, |d 1959- |7 xx0060352 |% UČO 1318 |4 ths | |
| 710 | 2 | |a Masarykova univerzita. |b Neurologická klinika, I. |7 stk2008421035 |4 dgg | |
| 856 | 4 | 1 | |u http://is.muni.cz/th/21360/lf_d/ |
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