MicroRNA expression analysis of selected hematological malignancies
MicroRNAs (miRNAs) are short 20-22 nucleotide RNA molecules that function as negative regulators of gene expression in eukaryotic organisms. RNA mediated gene silencing pathways have essential roles in development, cell differentiation, cell proliferation, cell death, chromosome structure and virus...
Uloženo v:
| Hlavní autor: | |
|---|---|
| Další autoři: | |
| Typ dokumentu: | VŠ práce nebo rukopis |
| Jazyk: | Angličtina |
| Vydáno: |
2008.
|
| Témata: | |
| On-line přístup: | http://is.muni.cz/th/101627/prif_m/ |
| LEADER | 04413ctm a22008297a 4500 | ||
|---|---|---|---|
| 001 | MUB01000554225 | ||
| 003 | CZ BrMU | ||
| 005 | 20160427130740.0 | ||
| 008 | 080628s2008 xr ||||| |||||||||||eng d | ||
| STA | |a POSLANO DO SKCR |b 2017-06-28 | ||
| 035 | |a (ISMU-VSKP)130404 | ||
| 040 | |a BOD114 |b cze |d BOD004 | ||
| 072 | 7 | |a 577 |x Biochemie. Molekulární biologie. Biofyzika |2 Konspekt |9 2 | |
| 080 | |a 577.21 |2 MRF | ||
| 080 | |a 616.155.392 |2 MRF | ||
| 080 | |a 577 |2 MRF | ||
| 100 | 1 | |a Mráz, Marek |7 xx0122131 |% UČO 101627 |4 dis | |
| 245 | 1 | 0 | |a MicroRNA expression analysis of selected hematological malignancies |h [rukopis] / |c Marek Mráz. |
| 246 | 3 | 1 | |a Analýza exprese microRNA u vybraných hematologických malignit |
| 260 | |c 2008. | ||
| 300 | |a 56 l. : |b il. | ||
| 500 | |a Vedoucí práce: Šárka Pospíšilová. | ||
| 502 | |a Diplomová práce (Mgr.)--Masarykova univerzita, Lékařská fakulta, 2008. | ||
| 520 | 2 | 9 | |a MicroRNAs (miRNAs) are short 20-22 nucleotide RNA molecules that function as negative regulators of gene expression in eukaryotic organisms. RNA mediated gene silencing pathways have essential roles in development, cell differentiation, cell proliferation, cell death, chromosome structure and virus resistance. These highly conserved RNAs regulating gene expression constitute about 3-5% of predicted genes in animals genomes, and 20-30% of protein-coding genes are probably regulated by miRNAs. MiRNAs are associated with RNA-induced silencing complex (RISC), which was identified before to repress the translation of mRNA by RNA interference (RNAi) mechanism. MiRNAs associate with RISC and bind to target mRNAs through partly complementary sequences and repress their translation. It results in the decresed level of the protein encoded by the mRNA. A single miRNA can bind multiple genes (based on incomplete complementarity) and have a possible profound effect on cell physiology. Moreover, ma. |9 eng |
| 650 | 0 | 7 | |a chronická lymfocytární leukémie |7 ph232604 |2 czenas |
| 650 | 0 | 7 | |a molekulární genetika |7 ph122957 |2 czenas |
| 650 | 0 | 9 | |a chronic lymphocytic leukemia |2 eczenas |
| 650 | 0 | 9 | |a molecular genetics |2 eczenas |
| 655 | 7 | |a diplomové práce |7 fd132022 |2 czenas | |
| 655 | 9 | |a master's theses |2 eczenas | |
| 658 | |a Biologie |b Molekulární biologie a genetika |c PřF N-BI BIMG (BIMG) |2 CZ-BrMU | ||
| 700 | 1 | |a Pospíšilová, Šárka, |d 1969- |7 xx0101843 |% UČO 38791 |4 ths | |
| 710 | 2 | |a Masarykova univerzita. |b Ústav experimentální biologie |7 mzk2008412438 |4 dgg | |
| 856 | 4 | 1 | |u http://is.muni.cz/th/101627/prif_m/ |
| CAT | |c 20080628 |l MUB01 |h 0451 | ||
| CAT | |a ANTLOVA |b 02 |c 20090316 |l MUB01 |h 1105 | ||
| CAT | |a JANA |b 02 |c 20090319 |l MUB01 |h 1451 | ||
| CAT | |a BATCH-UPD |b 02 |c 20091102 |l MUB01 |h 0648 | ||
| CAT | |a BATCH-UPD |b 02 |c 20091103 |l MUB01 |h 0150 | ||
| CAT | |c 20091203 |l MUB01 |h 0214 | ||
| CAT | |c 20091203 |l MUB01 |h 1856 | ||
| CAT | |a BATCH-UPD |b 00 |c 20091219 |l MUB01 |h 0757 | ||
| CAT | |c 20100428 |l MUB01 |h 1010 | ||
| CAT | |a BATCH-UPD |b 00 |c 20100501 |l MUB01 |h 1156 | ||
| CAT | |a BATCH-UPD |b 00 |c 20100929 |l MUB01 |h 0331 | ||
| CAT | |a POSPEL |b 02 |c 20110118 |l MUB01 |h 1351 | ||
| CAT | |c 20110627 |l MUB01 |h 1913 | ||
| CAT | |c 20110627 |l MUB01 |h 2321 | ||
| CAT | |a batch |b 00 |c 20120324 |l MUB01 |h 0115 | ||
| CAT | |a POSPEL |b 02 |c 20120412 |l MUB01 |h 0943 | ||
| CAT | |a POSPEL |b 02 |c 20120412 |l MUB01 |h 0947 | ||
| CAT | |c 20120610 |l MUB01 |h 1926 | ||
| CAT | |a HANAV |b 02 |c 20120718 |l MUB01 |h 1242 | ||
| CAT | |a BATCH |b 00 |c 20130303 |l MUB01 |h 1013 | ||
| CAT | |a POSPEL |b 02 |c 20140109 |l MUB01 |h 1209 | ||
| CAT | |c 20150901 |l MUB01 |h 1442 | ||
| CAT | |c 20150921 |l MUB01 |h 1403 | ||
| CAT | |a BATCH |b 00 |c 20151225 |l MUB01 |h 2336 | ||
| CAT | |a HANAV |b 02 |c 20160208 |l MUB01 |h 1150 | ||
| CAT | |a DRIMLOVAX |b 02 |c 20160427 |l MUB01 |h 1248 | ||
| CAT | |a DRIMLOVA |b 02 |c 20160427 |l MUB01 |h 1307 | ||
| CAT | |c 20170628 |l MUB01 |h 1109 | ||
| CAT | |c 20210614 |l MUB01 |h 0933 | ||
| CAT | |c 20210614 |l MUB01 |h 1921 | ||
| CAT | |a BATCH |b 00 |c 20210724 |l MUB01 |h 1138 | ||
| CAT | |c 20240209 |l MUB01 |h 1157 | ||
| CAT | |a POSPEL |b 02 |c 20240304 |l MUB01 |h 1058 | ||
| CAT | |a POSPEL |b 02 |c 20240506 |l MUB01 |h 1057 | ||
| LOW | |a POSLANO DO SKCR |b 2017-06-28 | ||
| 994 | - | 1 | |l MUB01 |l MUB01 |m VYSPR |1 KUK |a Knihovna univ. kampusu |2 SKLAD |b KUK - sklad |3 PřF-K-11896 |5 3145344512 |8 20090316 |f 71 |f Prezenční SKLAD |r 20090316 |s převod |
| AVA | |a MED50 |b KUK |c KUK - sklad |d PřF-K-11896 |e available |t K dispozici |f 1 |g 0 |h N |i 0 |j SKLAD | ||