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180803s2015 sz |||||o|||||||||||eng d |
| STA |
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|a EIZ
|b 333
|c EBSCO trvale nakupy
|d 2018-07-31
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| 020 |
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|a 978-3-319-19096-9
|q (eBook)
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| 035 |
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|a (OCoLC)ocn922698113
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| 035 |
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|a (OCoLC)922698113
|z (OCoLC)931591659
|z (OCoLC)932332938
|z (OCoLC)985040292
|z (OCoLC)1005824427
|z (OCoLC)1011905614
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|a N$T
|b cze
|e rda
|c N$T
|d N$T
|d YDXCP
|d IDEBK
|d OCLCF
|d CDX
|d EBLCP
|d NUI
|d COO
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|d GW5XE
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|d Z5A
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| 245 |
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|a Studies on experimental toxicology and pharmacology /
|c Stephen M. Roberts, James P. Kehrer and Lars-Oliver Klotz, editors ; editor in chief: Donald Armstrong
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| 264 |
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|a Cham :
|b Humana Press,
|c 2015
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| 300 |
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|a 1 online zdroj (xvi, 498 stran) :
|b ilustrace
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a počítač
|b c
|2 rdamedia
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| 338 |
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|a online zdroj
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Oxidative stress in applied basic research and clinical practice,
|x 2197-7224
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| 505 |
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|a Contributors; Biographies of Editors; Part I: Toxicological Mechanisms and Evaluation of Oxidative Stress; Chapter 1: A Historical Perspective on Oxidative Stress and Intracellular Redox Control; 1.1 Introduction; 1.2 The Search for the Grandmaster; 1.3 The Pre-paradigm Era; 1.4 The 1980s and the Emergence of More General Concepts; 1.5 Puzzle Solving; 1.6 Clouds on the Horizon; 1.7 The Journey to the Cysteine Chapel; 1.8 The Rise, Demise and Renaissance of the Antioxidant; 1.9 Conclusions; References; Chapter 2: An Overview of Free Radicals as Causes and Consequences of Toxicity.
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| 505 |
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|a 2.1 Introduction2.2 Radical Chemistry; 2.3 Characteristic Oxidative Reactions; 2.3.1 Proteins and Peptides; 2.3.2 Lipids; 2.3.3 DNA; 2.3.4 Apoptosis; 2.3.5 Role of Metal Ions; 2.4 Summary; References; Chapter 3: Oxidants, Radicals, Free Radicals, and Other Bad Stuff in Mechanisms of Toxicity; 3.1 Free Radicals and Reactivity; 3.2 It Is Well-Known That; 3.3 Conclusions; References; Chapter 4: Lipid Oxidation; 4.1 Introduction; 4.2 Types of Lipid Oxidation; 4.2.1 Enzymatic Oxidation of Lipids; 4.2.2 Non-enzymatic Oxidation of Lipids; 4.3 Reactivity of Lipid Oxidation Products.
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| 505 |
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|a 4.4 Types of Biological Effects4.4.1 Effects on Cell Membranes; 4.4.2 Toxicity; 4.4.3 Pro-inflammatory or Deleterious Effects; 4.4.4 Cytoprotective Effects; 4.5 Mechanisms of Biological Effects: Interactions with Receptors and Signalling Pathways; 4.6 Metabolism; 4.7 Effects of Other Lipid Modifications; 4.8 Analysis of Lipid Oxidation; 4.9 Oxidized Lipids and Therapeutics; 4.10 Summary and Perspectives; References; Chapter 5: Protein Oxidation in Toxicology; 5.1 Introduction; 5.2 Oxidative Stress and Protein Oxidation; 5.3 The Chemistry of Protein Oxidation; 5.3.1 Backbone Damage.
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| 505 |
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|a 5.3.2 Side-Chain Damage5.3.2.1 Aliphatic Amino Acid Residues; 5.3.2.2 Aromatic Amino Acid Residues; 5.3.2.3 Sulfur-Containing Amino Acid Residues; 5.3.2.4 Carbonyl Group Formation; 5.4 Consequences of Protein Oxidation; 5.5 Repair and Degradation of Oxidatively Damaged Proteins; 5.5.1 Repair Systems; 5.5.1.1 Repair of Disulfides; 5.5.1.2 Repair of Methionine Sulfoxides; 5.5.2 Degradation Systems; 5.5.2.1 The Proteasomal System; 5.5.2.2 The Lysosomal System; 5.6 Reactive Species and Protein Oxidation: Roles in Toxicology; 5.6.1 Toxins Might Be Reactive Species.
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| 505 |
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|a 5.6.2 Toxins Are Metabolized to Reactive Species5.6.3 Reactive Species Are Generated in Redox Cycling of Toxins; 5.6.4 Toxins Interfere with the Antioxidant Defense System; 5.6.5 Toxins Increase the Endogenous RS generation; 5.6.5.1 Mitochondrial Electron Transport Chain; 5.6.5.2 Cytochrom P450 System; 5.6.6 Toxins Provoking the Immune Response; 5.7 Conclusion; References; Chapter 6: Oxidative Stress and DNA Damage Association with Carcinogenesis: A Truth or a Myth?; 6.1 Introduction; 6.2 Toxic Forms of Oxygen and Primary Reactions; 6.3 Types of Oxidative DNA Damage; 6.3.1 Base Damage.
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| 533 |
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|a Elektronická reprodukce.
|n Přístup pouze pro oprávněné uživatele
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| 650 |
0 |
7 |
|a toxikologie
|7 ph116469
|2 czenas
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| 650 |
0 |
7 |
|a farmakologie
|7 ph114526
|2 czenas
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| 650 |
0 |
9 |
|a toxicology
|2 eczenas
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| 650 |
0 |
9 |
|a pharmacology
|2 eczenas
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| 655 |
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7 |
|a e-knihy online
|2 CZ-BrMU
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| 655 |
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9 |
|a e-books online
|2 eCZ-BrMU
|
| 700 |
1 |
|
|a Armstrong, Donald
|4 edt
|
| 700 |
1 |
|
|a Roberts, Stephen M.,
|d 1950-
|7 xx0219923
|4 edt
|
| 700 |
1 |
|
|a Kehrer, James P.,
|d 1951-
|7 ntk20201076968
|4 edt
|
| 700 |
1 |
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|a Klotz, Lars-Oliver,
|d 1969-
|7 ntk20201076958
|4 edt
|
| 776 |
0 |
8 |
|i Tištěná verze:
|t Studies on experimental toxicology and pharmacology.
|z 978-3-319-19095-2
|
| 830 |
|
0 |
|a Oxidative stress in applied basic research and clinical practice,
|x 2197-7224
|
| 856 |
4 |
1 |
|z Elektronická verze přístupná pouze pro studenty a pracovníky MU
|u https://ezproxy.muni.cz/login?url=https://search.ebscohost.com/login.aspx?authtype=ip&custid=s8431878&lang=cs&profile=eds&direct=true&db=nlebk&AN=1075359
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