Pharmacokinetics and toxicokinetics /

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Hlavní autor: Boroujerdi, Mehdi (Autor)
Typ dokumentu: Kniha
Jazyk:Angličtina
Vydáno: Boca Raton, FL : CRC Press, [2015]
Témata:
On-line přístup:Elektronická verze přístupná pouze pro studenty a pracovníky MU
Příbuzné jednotky:Tištěná verze:: Pharmacokinetics and toxicokinetics.
Obsah:
  • Chapter 1. The influence of routes of administration on ADME
  • chapter 2. Mechanisms of absorption and permeation of xenobiotics
  • chapter 3. In Vivo distribution of xenobiotics
  • chapter 4. Elimination rate, clearance, and the theoretical models
  • chapter 5. Renal excretion of xenobiotics and estimation of related PK/TK parameters and constants
  • chapter 6. Biotransformation of xenobiotics
  • chapter 7. Kinetics of In Vitro metabolism : assimilation of intrinsic clearance in hepatic clearance
  • chapter 8. Pharmaceutical, biopharmaceutical, and physiological factors influencing oral absorption : mechanistic absorption models
  • chapter 9. Mathematical modeling in pharmacokinetics and toxicokinetics
  • chapter 10. PK/TK analysis of instantaneous exposure to xenobiotics (single bolus injection)
  • chapter 11. PK/TK analysis of continuous zero-order exposure to xenobiotics (intravenous infusion)
  • chapter 12. PK/TK analysis of xenobiotics absorbed via an extravascular route of administration (oral administration)
  • chapter 13. PK/TK of xenobiotics absorbed through the skin (transdermal absorption)
  • chapter 14. PK/TK analysis of multiple dosing
  • chapter 15. Bioavailability, bioequivalence, and biosimilar evaluations
  • chapter 16. Preclinical PK/TK and clinical trials
  • chapter 17. Population pharmacokinetics/toxicokinetics
  • chapter 18. Quantitative extrapolation interspecies scaling/low dose extrapolation