The molecular biology of cancer : a bridge from bench to bedside /
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| Další autoři: | , |
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| Typ dokumentu: | Kniha |
| Jazyk: | Angličtina |
| Vydáno: |
Chichester :
Wiley-Blackwell,
2013
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| Vydání: | Second edition |
| Témata: | |
| On-line přístup: | Elektronická verze přístupná pouze pro studenty a pracovníky MU |
| Příbuzné jednotky: | Tištěná verze::
Molecular biology of cancer. |
Obsah:
- Cover; Title page; Copyright page; Contents; Contributors; Preface to the Second Edition; Acknowledgments; Dedication; About the Companion Website; Introduction; 1: Overview of Cancer Biology; Introduction; Cancer incidence and epidemiology; Towards a definition of cancer; Classification of cancer; It is surprisingly difficult to define cancer in practice; Cancers may not always be clinically apparent; If we find a cancer what do we do with it?; Causes of cancer; The clonal evolution theory; Becoming a cancer cell
- multistage carcinogenesis; The cell of origin in cancer.
- The cancer stem cell and nicheA chemotherapy-resistant niche; Targeting the cancer-initiating cells; The latent niche; Cancer is a genetic disease; Cancers (and Darwin's finches) evolve by mutation and natural selection; Blame the parents
- inherited single gene defects and susceptibility to cancer; Loss of heterozygosity and comparative genome hybridization; Haploinsufficiency; Blame everyone
- complex polygenic mechanisms and inherited susceptibility to cancer; An apology to Jean-Baptiste Lamarck: cancer is an epigenetic disease (but you were wrong about giraffes).
- "So it isn't really junk after all." Noncoding DNAThe cancer "roadmap"
- What kinds of genes are epimutated in cancer?; Viruses and the beginnings of cancer biology; Hens and teeth or bears and woods? The hens have it
- cancer is rare; The barriers to cancer; The tumor suppressors; Avoiding suicidal urges; Other forms of death; Avoiding senescence; Oncogene-induced senescence; Oncogenes as tumor suppressors; What is the secret of cancer developme ... "timing"; Location, location, location
- the cancer environment: nanny or spartan state; Cancer cells as "cuckoos."
- Cancers, chronic inflammation, and tissue remodelingLiaisons dangereuses encourage tumorigenesis; Policemen or agent provocateur
- immunocytes in cancer; Cancer goes agricultural; The field effect; The seed and the soil: metastatic spread; Cancer superhighways
- blood vessels and lymphatics; On your bike and turn the lights off before you go; Catching cancer; Hammering the hallmarks; Cancer
- Achilles' heel and Paris' arrow; Getting the GIST of oncogene addiction; Cooking with ERBBs; Painting a portrait of cancer; Savile Row tailoring of cancer therapies; The pitfalls of tumor profiling.
- A cancer protein expression profileThe drugs don't work; The addictive personality of cancer
- synthetic lethality and non-oncogene addiction; Mechanism of origin rather than cell of origin
- towards a new functional taxonomy of cancer; Is it worth it?; Conclusions and future directions; Bibliography; Appendix 1.1 History of cancer; 2: The Burden of Cancer; Introduction; Lung cancer; Incidence; Pathology; Clinical features; Diagnostic and staging investigations; Treatment; Breast cancer; Pathology; Clinical features; Diagnostic procedures and investigations; Treatment; Chemotherapy.