Comparative proteomic analysis of Francisella tularensis subspecies and characterization of unique proteins by mass spectrometry
Předkládaná práce shrnuje výsledky proteomických studií patogenní bakterie Francisella tularensis s cílem; i) sledovat změny na úrovni proteomu mezi jednotlivými poddruhy této bakterie; ii) aplikace těchto výsledků do experimentů ve výzkumu patogeneze Francisella tularensis a iii) aplikace proteomic...
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| Typ dokumentu: | VŠ práce nebo rukopis |
| Jazyk: | Angličtina |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | http://is.muni.cz/th/75926/prif_d/ |
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| 072 | 7 | |a 577 |x Biochemie. Molekulární biologie. Biofyzika |2 Konspekt |9 2 | |
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| 100 | 1 | |a Hubálek, Martin, |d 1976- |7 xx0142582 |% UČO 75926 |4 dis | |
| 245 | 1 | 0 | |a Comparative proteomic analysis of Francisella tularensis subspecies and characterization of unique proteins by mass spectrometry |h [elektronický zdroj] / |c Martin Hubálek |
| 246 | 1 | 1 | |a Komparativní proteomová analýza mikrobů Francisella tularensis s identifikací jedinečných proteinů hmotnostní spektrometrií |
| 260 | |c 2007 | ||
| 300 | |a 1 CD-ROM | ||
| 500 | |a Vedoucí práce: Igor Kučera | ||
| 502 | |a Dizertace (Ph.D.)--Masarykova univerzita, Přírodovědecká fakulta, 2007 | ||
| 520 | 2 | |a Předkládaná práce shrnuje výsledky proteomických studií patogenní bakterie Francisella tularensis s cílem; i) sledovat změny na úrovni proteomu mezi jednotlivými poddruhy této bakterie; ii) aplikace těchto výsledků do experimentů ve výzkumu patogeneze Francisella tularensis a iii) aplikace proteomických technik v bakteriální identifikaci a typizaci. Počáteční experimenty byly zaměřeny na mapování komplexní proteinové směsi celých bakteriálních lyzátů pomocí dvoudimensionální elektroforézy (2-DE). |% cze | |
| 520 | 2 | 9 | |a The main goals of the work presented were to investigate: i) subspecies variations of pathogenic bacterium Francisella tularensis on proteome level; ii) the possible mechanisms of Francisella tularensis pathogenesis and iii) the possibilities to use proteomics techniques for bacterial identification and typing. The initial experiments were aimed at mapping the complex protein mixture of whole cell lysate by two-dimensional electrophoresis (2-DE). The platform of 2-DE database has been established and interactive web based data are available (http://web.mpiib-berlin.mpg.de/cgi-bin/pdbs/2d-page/extern/ind ex.cgi). Once the reliable and reproducible system of 2-DE separation was achieved the follow-up experiments that utilize the platform were initiated. Comparative analyses of three Francisella tularensis subspecies was started soon after the first successful 2-DE experiments and resulted in identification of 2 DE spots corresponding to proteins with different expression patterns in the three subspecies. |9 eng |
| 650 | 0 | 7 | |a biochemie |7 ph114149 |2 czenas |
| 650 | 0 | 7 | |a hmotnostní spektrometrie |7 ph120763 |2 czenas |
| 650 | 0 | 9 | |a biochemistry |2 eczenas |
| 650 | 0 | 9 | |a mass spectroscopy |2 eczenas |
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| 700 | 1 | |a Kučera, Igor, |d 1955- |7 ola2003204898 |% UČO 911 |4 ths | |
| 710 | 2 | |a Masarykova univerzita. |b Ústav biochemie |7 ko2015866760 |4 dgg | |
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